FORMULATION AND EVALUATION OF POLYHERBAL EMULGEL FOR MANAGEMENT OF RHEUMATOID ARTHRITIS

Abstract

Rheumatoid arthritis (RA) is a chronic autoimmune disorder characterized by inflammation and destruction of joints, leading to pain, stiffness, and impaired mobility. Conventional treatments often focus on managing symptoms and slowing disease progression, but they may come with side effects and limited efficacy. Herbal remedies have gained attention for their potential to alleviate RA symptoms with fewer adverse effects.This project aims to develop a polyherbal emulgel, a topical formulation, utilizing the synergistic effects of Vitex negundo, Curcuma longa, Piper nigrum, and Zingiber officinale, known for their anti-inflammatory, analgesic, and antioxidant properties. Vitex  negundo (Nirgundi) possesses anti-inflammatory and analgesic properties, while Curcuma longa (Turmeric) is known for its potent anti-inflammatory and antioxidant effects. Piper nigrum (Black Pepper) enhances the bioavailability of other herbal components, and Zingiberofficinale (Ginger) exhibits anti-inflammatory and analgesic properties.The emulgel formulation offers the advantage of both hydrophilic and lipophilic properties, ensuring better skin penetration and prolonged drug release. This project will involve the optimization of formulation parameters such as the concentration of herbal extracts, emulsifiers, and gelling agents to achieve the desired rheological and therapeutic properties .The developed polyherbal emulgel has the potential to provide symptomatic relief, reduce inflammation, and improve joint function in patients with rheumatoid arthritis, offering a safer and more holistic alternative to conventional therapies. The emulgel formulation was optimized for maximum efficacy and stability. Evaluation of the emulgel's physicochemical properties, such as pH, viscosity, and spreadability, stability testing ,rheogical behavior was conducted.