ETHOSOMES: AN AUGMENTED VESICULAR CARRIER FOR TRANSDERMAL DRUG DELIVERY

Abstract

Ethosomes systems are novel lipid vesicular carriers containing a relatively high percentage of ethanol. These nanocarriers are especially designed for the efficient delivery of therapeutic agents with different physicochemical properties into deep skin layers and across the skin. New compounds were added to their initial formula, which led to the production of new types of Ethosomes systems. Different preparation techniques are used in the preparation of these novel carriers. For ease of application and stability, Ethosomes dispersions are incorporated into gels, patches, and creams. Highly diverse in vivo models are used to evaluate their efficacy in transdermal.delivery, in addition to clinical trials. Ethosomes are categorised based on their constituents to classical Ethosomes, binary Ethosomes and transferosomes. The differences among these systems are discussed from several perspectives, including the formulation, size, zeta potential, entrapment efficiency, skin-permeation properties, and stability. The Ethosomes formulation showed good physical and chemical stability in a well closed container at an ambient temperature. This study gives a detailed review on the effects of Ethosomes system constituents, preparation methods, and their significant roles in determining the final properties of these nanocarriers. Furthermore, the recent and prospects of the Ethosomes are highlighted. Detailed information regarding the in-evaluation studies conducted in Ethosomes are discussed.